Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045291 | 0.80 | TYMS (0.38) | TYMSLMNANPC1MAPTRAB9A | |
| SCHEMBL15994595 | 0.76 | TDP1 (0.39) | TYMSLMNARAB9ATDP1L3MBTL1 | |
| SCHEMBL8791995 | 0.75 | CES1 (0.54) | LMNAMAPTRAB9ASMN1; SMN2TDP1 | |
| SCHEMBL670008 | 0.72 | KMT2A (0.35) | LMNANPC1MAPTRAB9AMEN1 | |
| SCHEMBL29457692 | 0.71 | ALDH1A1 (0.49) | LMNATDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL28262113 | 0.69 | KDM4E (0.39) | NPC1MAPTRAB9ASMN1; SMN2TDP1 | |
| SCHEMBL378548 | 0.69 | KDM4E (0.39) | NPC1MAPTRAB9ASMN1; SMN2TDP1 | |
| SCHEMBL31684807 | 0.69 | KDM4E (0.59) | TYMSLMNANPC1MAPTRAB9A | |
| SCHEMBL159416 | 0.69 | KDM4E (0.59) | TYMSLMNANPC1MAPTRAB9A | |
| SCHEMBL1674893 | 0.68 | TDP1 (0.43) | MAPTTDP1L3MBTL1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10987317-B2 | Inhibition of glutaminase C | CORNELL UNIVERSITY (US) | 2021-04-27 | — | — | US | disclosed |
| US-20200206149-A1 | INHIBITION OF GLUTAMINASE C | UNIV CORNELL (US) | 2020-07-02 | — | — | US | disclosed |
| US-20130252983-A1 | ACTIVATING PHOSPHORYLATION SITE ON GLUTAMINASE C | CORNELL UNIVERSITY (US) | 2013-09-26 | — | — | US | disclosed |
| US-20120220610-A1 | INHIBITIONS OF GLUTAMINASE C | CORNELL UNIVERSITY (US) | 2012-08-30 | — | — | US | disclosed |
| WO-2012034123-A1 | ACTIVATING PHOSPHORYLATION SITE ON GLUTAMINASE C | CORNELL UNIVERSITY (US) | 2012-03-15 | — | — | WO | disclosed |
| WO-2010111504-A2 | INHIBITION OF GLUTAMINASE C | CORNELL UNIVERSITY (US) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252983-A1 | ACTIVATING PHOSPHORYLATION SITE ON GLUTAMINASE C | GLS, GLUL, GLS2 | TYMS 1585/4885LMNA 3117/4885NPC1 4542/4885 |
| US-20200206149-A1 | INHIBITION OF GLUTAMINASE C | GLS, GLS2, GLUL | TYMS 1003/4885LMNA 4026/4885NPC1 4411/4885 |
| US-20120220610-A1 | INHIBITIONS OF GLUTAMINASE C | GLS, GLS2, GLUL | TYMS 826/4885LMNA 3975/4885NPC1 4432/4885 |
| US-10987317-B2 | Inhibition of glutaminase C | GLS, GLS2, GLUL | TYMS 1003/4885LMNA 4026/4885NPC1 4411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.