Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | TEK | Q02763 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5042862 | 0.89 | CD38 (0.44) | MEN1KMT2ANPC1RAB9AMET | |
| SCHEMBL5042842 | 0.88 | MAPT (0.42) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL7176912 | 0.87 | MAPT (0.39) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL5036681 | 0.87 | NPC1 (0.49) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL5042858 | 0.87 | NPC1 (0.50) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL7048978 | 0.85 | ACR (0.41) | MEN1KMT2ANPC1RAB9AMET | |
| SCHEMBL7049236 | 0.84 | MMP1 (0.38) | NPC1RAB9AMAPTALDH1A1HTT | |
| SCHEMBL7044404 | 0.84 | ROCK2 (0.37) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL7044049 | 0.83 | KDR (0.41) | MEN1KMT2ANPC1RAB9AMET | |
| SCHEMBL5040906 | 0.81 | NPC1 (0.46) | NPC1RAB9AMAPTCD38HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |