Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049344 | 0.91 | JAK2 (0.39) | JAK2JAK1TYK2JAK3KDM4D | |
| SCHEMBL7049353 | 0.86 | F2 (0.35) | ALDH1A1AVPR2KDM4EEPHX2 | |
| SCHEMBL6477345 | 0.86 | F2 (0.35) | ALDH1A1AVPR2KDM4EEPHX2 | |
| SCHEMBL7048665 | 0.81 | P2RX7 (0.41) | JAK3ENPP2ALDH1A1EPHX2 | |
| SCHEMBL7048588 | 0.80 | NAMPT (0.39) | JAK2JAK1 | |
| SCHEMBL7046882 | 0.77 | JAK2 (0.39) | JAK2JAK1TYK2JAK3KDM4D | |
| SCHEMBL7047781 | 0.76 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DEPHX2 | |
| SCHEMBL7045257 | 0.75 | DPP4 (0.37) | JAK2JAK1JAK3KDM4D | |
| SCHEMBL5901089 | 0.74 | EPHX1 (0.33) | ALDH1A1KDM4E | |
| SCHEMBL7049587 | 0.74 | F2 (0.33) | MMP2MMP13EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773955-B1 | NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE | BASF AG (DE) | 2003-04-16 | — | — | EP | disclosed |
| WO-1995035309-A1 | NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1995-12-28 | — | — | WO | disclosed |