Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049344 | 0.85 | JAK2 (0.39) | JAK2JAK1TYK2JAK3KDM4D | |
| SCHEMBL23775495 | 0.77 | ABCB1 (0.43) | JAK2JAK1TYK2JAK3KDM4D | |
| SCHEMBL30305200 | 0.77 | ABCB1 (0.43) | JAK2JAK1TYK2JAK3KDM4D | |
| SCHEMBL7045772 | 0.77 | JAK2 (0.40) | JAK2JAK1TYK2JAK3KDM4D | |
| SCHEMBL7048665 | 0.75 | P2RX7 (0.41) | JAK3DRD2ENPP2AAK1EPHX2 | |
| SCHEMBL7050773 | 0.71 | ALDH1A1 (0.42) | JAK2JAK1TYK2JAK3KDM4D | |
| SCHEMBL7047070 | 0.70 | ALDH1A1 (0.64) | JAK2JAK1TYK2JAK3EPHX2 | |
| SCHEMBL7045257 | 0.68 | DPP4 (0.37) | JAK2JAK1JAK3KDM4DAAK1 | |
| SCHEMBL5900918 | 0.68 | MEN1 (0.45) | DRD2MMP13ALDH1A1MMP1MMP9 | |
| SCHEMBL24838783 | 0.68 | TRPV1 (0.44) | DRD2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773955-B1 | NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE | BASF AG (DE) | 2003-04-16 | — | — | EP | disclosed |