Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052562 | 0.80 | CTSA (0.43) | CTSAACHEKDM4ETDP1TSHR | |
| SCHEMBL10395342 | 0.74 | CTSA (0.43) | CTSAACHEKDM4ETDP1ALDH1A1 | |
| SCHEMBL11737808 | 0.71 | CTSA (0.41) | CTSAACHEKDM4ETDP1TSHR | |
| SCHEMBL10029059 | 0.69 | ALDH1A1 (0.34) | CTSAACHEKDM4EALDH1A1POLB | |
| SCHEMBL18486500 | 0.69 | MMP1 (0.50) | CTSAACHEKDM4EALDH1A1KMT2A | |
| SCHEMBL6681748 | 0.69 | CTSA (0.50) | CTSAACHEKDM4ETDP1TSHR | |
| SCHEMBL268599 | 0.69 | CTSA (0.50) | CTSAACHEKDM4ETDP1TSHR | |
| Phosphorylisopropane SCHEMBL82996 | 0.69 | — | — | |
| SCHEMBL4832489 | 0.69 | CTSA (0.39) | CTSAACHEALDH1A1L3MBTL1HMGCR | |
| SCHEMBL80155 | 0.67 | CTSA (0.56) | CTSAACHEKDM4ETDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147245-A | Preparation and use of α-Keto Bisphosphonates | UNIVERSITY OF SOUTHERN CALIFORNIA UNIVERSITY PARK (US) | 2000-11-14 | — | — | US | claimed |
| US-20080200679-A1 | Alpha-HYDROXY, alpha-SUBSTITUTED METHYLENEBISPHOSPHONATES AND PHOSPHONOACETATES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2008-08-21 | — | — | US | disclosed |
| US-20080200679-A1 | Alpha-HYDROXY, alpha-SUBSTITUTED METHYLENEBISPHOSPHONATES AND PHOSPHONOACETATES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2008-08-21 | — | — | US | disclosed |
| WO-2003011221-A2 | PREPARATION AND USE OF α-KETO PHOSPHONATES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2003-02-13 | — | — | WO | disclosed |
| EP-1097160-A4 | PREPARATION AND USE OF ALPHA-KETO BISPHOSPHONATES | UNIV SOUTHERN CALIFORNIA (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1097160-A1 | PREPARATION AND USE OF ALPHA-KETO BISPHOSPHONATES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2001-05-09 | — | — | EP | disclosed |
| US-6147245-A | Preparation and use of α-Keto Bisphosphonates | UNIVERSITY OF SOUTHERN CALIFORNIA UNIVERSITY PARK (US) | 2000-11-14 | — | — | US | disclosed |
| WO-2000002889-A1 | PREPARATION AND USE OF α-KETO BISPHOSPHONATES | THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2000-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200679-A1 | Alpha-HYDROXY, alpha-SUBSTITUTED METHYLENEBISPHOSPHONATES AND PHOSPHONOACETATES | GRHPR, PHPT1, PHYKPL | CTSA 4432/4885ACHE 2071/4885KDM4E 3921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.