Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | TOP1 | P11387 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048480 | 0.89 | TOP1 (0.42) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7363637 | 0.77 | TPMT (0.56) | RAB9AALDH1A1LMNATOP1MAPT | |
| SCHEMBL7371498 | 0.75 | VCAM1 (0.51) | KMT2AMEN1CYP3A4ALDH1A1MAPK1 | |
| SCHEMBL7436807 | 0.75 | TPMT (0.43) | RAB9ASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL7049743 | 0.74 | BCL9 (0.41) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11166903 | 0.74 | MEN1 (0.41) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL7373621 | 0.73 | L3MBTL1 (0.48) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL9253473 | 0.73 | LMNA (0.51) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8728378 | 0.72 | KMT2A (0.42) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7282357 | 0.71 | KMT2A (0.48) | SMN1; SMN2KMT2AMEN1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010688-B1 | Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them | PORTELA & CA SA (PT) | 2003-04-09 | — | — | EP | disclosed |
| US-6512136-B1 | Hypotensive, antiedemic agents; gastrointestinal disorders; Parkinson*s disease treatment | PORTELA & C.A., S.A. (PT) | 2003-01-28 | — | — | US | disclosed |
| EP-1010688-A1 | Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them | Portela & Ca., S.A. (PT) | 2000-06-21 | — | — | EP | disclosed |