Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046410 | 0.91 | MAOA (0.67) | MAOANPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL25524522 | 0.89 | MAOA (0.60) | MAOANPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL394209 | 0.80 | MAOA (1.00) | MAOANPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL30536437 | 0.78 | MAOA (0.72) | MAOANPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL20594364 | 0.78 | MAOA (0.72) | MAOANPC1RAB9APOLBL3MBTL1 | |
| Ethylene SCHEMBL18528476 | 0.78 | MAOA (0.94) | MAOANPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL392389 | 0.77 | MAOA (0.70) | MAOANPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL30130333 | 0.77 | MAOA (0.70) | MAOANPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL9413588 | 0.77 | NPC1 (0.68) | MAOANPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL10614660 | 0.76 | NPC1 (1.00) | MAOANPC1RAB9APOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608089-B2 | Having antiproliferative activity and are useful as modulators of multiple drug resistance in cancer chemotherapy of neoplasms, for use in manufacture of medicament for menopausal disorders and osteoporosis | INDENA S.P.A. (IT) | 2003-08-19 | — | — | US | disclosed |
| EP-1212312-B1 | NOVEL DERIVATIVES OF FLAVONES, XANTHONES AND COUMARINS | INDENA SPA (IT) | 2003-04-02 | — | — | EP | disclosed |
| US-20020183318-A1 | Having antiproliferative activity and are useful as modulators of multiple drug resistance in cancer chemotherapy of neoplasms, for use in manufacture of medicament for menopausal disorders and osteoporosis | INDENA S.P.A. (IT) | 2002-12-05 | — | — | US | disclosed |
| EP-1212312-A1 | NOVEL DERIVATIVES OF FLAVONES, XANTHONES AND COUMARINS | INDENA S.p.A. (IT) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001017985-A1 | NOVEL DERIVATIVES OF FLAVONES, XANTHONES AND COUMARINS | INDENA S.P.A. (IT) | 2001-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183318-A1 | Having antiproliferative activity and are useful as modulators of multiple drug resistance in cancer chemotherapy of neoplasms, for use in manufacture of medicament for menopausal disorders and osteoporosis | BRCA1, NCEH1, EZH1 | MAOA 3604/4885NPC1 29/4885RAB9A 4008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.