SCHEMBL7047558

SCHEMBL7047558

CCOC(=O)c1cc2c(n1S(=O)(=O)c1ccc(Cl)c(Cl)c1)CCCC2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOD2 Q9HC29 4/20 0.47
NOD1 Q9Y239 4/20 0.47
CYP3A4 P08684 1/20 0.45
GAA P10253 1/20 0.45
CYP2C19 P33261 1/20 0.45
ALDH1A1 P00352 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.41
LMNA P02545 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
KDM4E B2RXH2 1/20 0.41
TSHR P16473 1/20 0.41
CYP2C9 P11712 1/20 0.41
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40
MAPK1 P28482 1/20 0.40
KMT2A Q03164 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.40
SLC6A2 P23975 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7049774 0.88 SLC6A2 (0.42) NOD1ALDH1A1SMN1; SMN2LMNAL3MBTL1
SCHEMBL7050238 0.83 CCR2 (0.56) NOD1CYP3A4L3MBTL1TSHRMEN1
SCHEMBL7047270 0.77 MAPT (0.48) NOD2NOD1GAAALDH1A1SMN1; SMN2
SCHEMBL7969831 0.76 MAPT (0.47) NOD2NOD1GAAALDH1A1SMN1; SMN2
SCHEMBL13562331 0.72 NOD2 (0.56) NOD2NOD1ALDH1A1SMN1; SMN2LMNA
SCHEMBL27968907 0.70 ALDH1A1 (0.47) GAACYP2C19ALDH1A1SMN1; SMN2LMNA
SCHEMBL12777540 0.70 ALDH1A1 (0.47) GAACYP2C19ALDH1A1LMNAL3MBTL1
SCHEMBL1655571 0.69 NOD2 (0.43) NOD2NOD1GAAALDH1A1LMNA
SCHEMBL1393341 0.69 ALDH1A1 (0.44) NOD2NOD1GAACYP2C19ALDH1A1
SCHEMBL9100639 0.69 MAPK1 (0.45) GAACYP2C19ALDH1A1SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1054667-B1 BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS ASTRAZENECA UK LTD (GB) 2003-04-16 EP disclosed
US-6291507-B1 INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES ASTRAZENECA UK LIMITED (GB) 2001-09-18 US disclosed
EP-1054667-A1 BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS AstraZeneca UK Limited (GB) 2000-11-29 EP disclosed
WO-1999040913-A1 CHEMICAL COMPOUNDS ASTRAZENECA UK LIMITED (GB) 1999-08-19 WO disclosed