Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CCR2 | P41597 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047270 | 0.99 | MAPT (0.48) | MAPTSMN1; SMN2LMNAHTTGAA | |
| SCHEMBL9098048 | 0.86 | MAPT (0.55) | MAPTSMN1; SMN2LMNAGAAALDH1A1 | |
| SCHEMBL7947056 | 0.83 | CCR2 (0.55) | MAPTLMNARAB9ACCR2ABCB11 | |
| SCHEMBL7052102 | 0.82 | CCR2 (0.56) | CCR2ABCB11 | |
| SCHEMBL7954271 | 0.77 | LMNA (0.50) | MAPTSMN1; SMN2LMNAHTTGAA | |
| SCHEMBL6307761 | 0.77 | NOD2 (0.60) | MAPTSMN1; SMN2LMNAHTTGAA | |
| SCHEMBL6302415 | 0.77 | MAPT (0.51) | MAPTSMN1; SMN2LMNAHTTGAA | |
| SCHEMBL7046362 | 0.77 | HDAC1 (0.51) | MAPTSMN1; SMN2LMNAHTTGAA | |
| SCHEMBL12584597 | 0.76 | MAPT (0.55) | MAPTLMNAGAAKDM4ETDP1 | |
| SCHEMBL7047558 | 0.76 | NOD2 (0.47) | MAPTSMN1; SMN2LMNAGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |