Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.64 |
| ▸ | DRD3 | P35462 | 9/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.61 |
| ▸ | HTR7 | P34969 | 3/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | DRD5 | P21918 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047855 | 0.96 | DRD2 (0.64) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL8141289 | 0.88 | DRD2 (0.61) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL7455896 | 0.88 | SIGMAR1 (0.56) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL7674560 | 0.84 | DRD2 (0.62) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL12468732 | 0.81 | DRD2 (0.54) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL11465528 | 0.80 | SIGMAR1 (0.76) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL4608279 | 0.80 | DRD2 (0.53) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL8141285 | 0.79 | DRD2 (0.49) | DRD2DRD3ADRA1AHTR7DRD5 | |
| SCHEMBL21511115 | 0.78 | KCNH2 (0.54) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL1253143 | 0.78 | SIGMAR1 (0.69) | DRD2DRD3ADRA1ASIGMAR1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771197-B1 | USE OF HETEROCYCLIC COMPOUNDS AS DOPAMINES-D 3- LIGANDS | BASF AG (DE) | 2003-04-09 | — | — | EP | disclosed |
| US-6090807-A | Use of heterocyclic compounds | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-18 | — | — | US | disclosed |