Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.64 |
| ▸ | DRD3 | P35462 | 9/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | HTR7 | P34969 | 6/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | DRD5 | P21918 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | HTR6 | P50406 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047571 | 0.96 | DRD2 (0.64) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL7674560 | 0.89 | DRD2 (0.62) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL8141289 | 0.84 | DRD2 (0.61) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL7455896 | 0.84 | SIGMAR1 (0.56) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL8129982 | 0.79 | SIGMAR1 (0.70) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL11465528 | 0.78 | SIGMAR1 (0.76) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL7677748 | 0.78 | SIGMAR1 (0.54) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| 2-Mercaptopyridine SCHEMBL8140323 | 0.78 | DRD2 (0.64) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL12468732 | 0.78 | DRD2 (0.54) | DRD2DRD3ADRA1ASIGMAR1HTR7 | |
| SCHEMBL8128060 | 0.78 | SIGMAR1 (0.71) | DRD2DRD3ADRA1ASIGMAR1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771197-B1 | USE OF HETEROCYCLIC COMPOUNDS AS DOPAMINES-D 3- LIGANDS | BASF AG (DE) | 2003-04-09 | — | — | EP | disclosed |
| US-6090807-A | Use of heterocyclic compounds | BASF AKTIENGESELLSCHAFT (DE) | 2000-07-18 | — | — | US | disclosed |
| EP-0771197-A1 | USE OF HETEROCYCLIC COMPOUNDS AS DOPAMINES-D 3? LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996002246-A1 | USE OF HETEROCYCLIC COMPOUNDS AS DOPAMINES-D3 LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 1996-02-01 | — | — | WO | disclosed |