Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7039773 | 0.81 | NR1H3 (0.33) | ALDH1A1CACNA1GCACNA1BCACNA1CRXRA | |
| SCHEMBL17336687 | 0.81 | LMNA (0.36) | ALDH1A1CACNA1GCACNA1BCACNA1CMAPT | |
| SCHEMBL17336893 | 0.80 | NOTUM (0.36) | CACNA1GCACNA1BCACNA1CRXRANR1H2 | |
| SCHEMBL5558208 | 0.78 | RBP4 (0.36) | — | |
| SCHEMBL6872851 | 0.78 | RXRA (0.36) | ALDH1A1CACNA1GCACNA1BCACNA1CRXRA | |
| SCHEMBL7045105 | 0.77 | LMNA (0.33) | CACNA1GCACNA1BCACNA1CRXRANR1H2 | |
| SCHEMBL7113987 | 0.76 | RXRA (0.35) | ALDH1A1RXRANR1H2NR1H3LMNA | |
| SCHEMBL6881881 | 0.75 | SLC6A9 (0.45) | ALDH1A1MAPTLMNAHTT | |
| SCHEMBL6607932 | 0.74 | LMNA (0.35) | ALDH1A1MAPTRXRANR1H2NR1H3 | |
| SCHEMBL6622947 | 0.71 | POLQ (0.35) | ALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474416-A1 | DIHYDROBENZODIAZEPIN-2-ONE-DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003066623-A1 | DIHYDROBENZODIAZEPIN-2-ONE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-14 | — | — | WO | disclosed |