Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 8/20 | 0.54 |
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680682 | 0.96 | SIGMAR1 (0.53) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL7674560 | 0.81 | DRD2 (0.62) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL12468732 | 0.80 | DRD2 (0.54) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL7677755 | 0.79 | SIGMAR1 (0.55) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL4608504 | 0.79 | HTR7 (0.53) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL12469317 | 0.78 | NPSR1 (0.61) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL7047855 | 0.78 | DRD2 (0.64) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL4608940 | 0.77 | ALDH1A1 (0.53) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL11465528 | 0.77 | SIGMAR1 (0.76) | SIGMAR1HTR7DRD2DRD3ADRA1A | |
| SCHEMBL13875122 | 0.76 | SIGMAR1 (0.71) | SIGMAR1HTR7DRD2DRD3ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403593-B1 | DOPAMINE RECEPTOR | ABBOTT LABORATORIES | 2002-06-11 | — | — | US | disclosed |
| US-6124294-A | COMPOUNDS HAVING HIGH AFFINITY FOR DOPAMINE D3 RECEPTOR; USED TO TREAT DISORDERS WHICH RESPOND TO DOPAMINE D3 LIGANDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-09-26 | — | — | US | disclosed |
| EP-0772604-B1 | TRIAZOLE COMPOUNDS AND THEIR USE AS DOPAMINE-D3-LIGANDS | BASF AG (DE) | 1999-05-06 | — | — | EP | disclosed |