Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.31 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7118144 | 0.96 | CYP19A1 (0.34) | CYP19A1GPR3HTR2ASLC22A2SLC22A3 | |
| Hydrochloric Acid SCHEMBL7049650 | 0.96 | CYP19A1 (0.34) | CYP19A1GPR3HTR2ASLC22A2SLC22A3 | |
| Hydrochloric Acid SCHEMBL7056966 | 0.96 | CYP19A1 (0.34) | CYP19A1GPR3HTR2ASLC22A2SLC22A3 | |
| SCHEMBL7050222 | 0.96 | GPR3 (0.35) | CYP19A1GPR3HTR2ASLC22A2SLC22A3 | |
| Hydrochloric Acid SCHEMBL7049642 | 0.92 | GPR3 (0.33) | CYP19A1GPR3HTR2ASLC22A2SLC22A3 | |
| Hydrochloric Acid SCHEMBL7048569 | 0.92 | GPR3 (0.33) | CYP19A1GPR3HTR2ASLC22A2SLC22A3 | |
| Hydrochloric Acid SCHEMBL7056957 | 0.92 | GPR3 (0.33) | CYP19A1GPR3HTR2ASLC22A2SLC22A3 | |
| Hydrochloric Acid SCHEMBL7118139 | 0.92 | GPR3 (0.33) | CYP19A1GPR3HTR2ASLC22A2SLC22A3 | |
| SCHEMBL6656917 | 0.79 | GPR3 (0.35) | CYP19A1GPR3HTR2ASLC22A2SLC22A3 | |
| SCHEMBL8970877 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1304319-A2 | Metallocenes and processes therefor and therewith | Phillips Petroleum Company (US) | 2003-04-23 | — | — | EP | disclosed |
| EP-0628566-B1 | Metallocenes and processes therefor and therewith | PHILLIPS PETROLEUM CO (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-0628566-A1 | Metallocenes and processes therefor and therewith | PHILLIPS PETROLEUM COMPANY (US) | 1994-12-14 | — | — | EP | disclosed |