Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.51 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.51 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 3/20 | 0.44 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5833504 | 0.96 | TACR1 (0.53) | TACR1FKBP4 | |
| SCHEMBL410223 | 0.92 | FKBP4 (0.54) | TACR1FKBP4 | |
| SCHEMBL522116 | 0.88 | TACR1 (0.44) | TACR1FKBP4PSMB9MMP3MMP1 | |
| SCHEMBL7355900 | 0.86 | TACR1 (0.51) | TACR1FKBP4 | |
| SCHEMBL1087550 | 0.86 | TACR1 (0.43) | TACR1FKBP4PSMB9MMP3MMP1 | |
| SCHEMBL7746384 | 0.85 | KMT2A (0.58) | TACR1FKBP4PSMB9KMT2A | |
| SCHEMBL7076149 | 0.85 | FKBP4 (0.56) | TACR1FKBP4 | |
| SCHEMBL3667052 | 0.84 | FKBP4 (0.58) | TACR1FKBP4KMT2A | |
| SCHEMBL6044127 | 0.84 | TACR1 (0.49) | TACR1FKBP4PSMB9KMT2AREN | |
| SCHEMBL3277774 | 0.82 | FKBP4 (0.57) | TACR1FKBP4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749443-B1 | FK-506 CYTOSOLIC BINDING PROTEIN | MERCK & CO INC (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-0749443-A4 | FK-506 CYTOSOLIC BINDING PROTEIN | MERCK & CO INC (US) | 1999-11-17 | — | — | EP | disclosed |
| US-5861498-A | GENETIC ENGINEERING AND NUCLEIC ACID MOLECULES AND CODING PROTEINS | THOMAS JEFFERSON UNIVERSITY (US) | 1999-01-19 | — | — | US | disclosed |
| EP-0749443-A1 | FK-506 CYTOSOLIC BINDING PROTEIN | MERCK & CO. INC. (US) | 1996-12-27 | — | — | EP | disclosed |
| WO-1996012018-A2 | NOVEL IMMUNOPHILINS AND CORRESPONDING NUCLEIC ACIDS | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1996-04-25 | — | — | WO | disclosed |
| US-5457182-A | An isolated, purified homogeneous polypeptide having a specific binding the immunosuppressant, but not cyclosporine | MERCK & CO., INC. (US) | 1995-10-10 | — | — | US | disclosed |
| WO-1995021861-A1 | FK-506 CYTOSOLIC BINDING PROTEIN | MERCK & CO., INC. (US) | 1995-08-17 | — | — | WO | disclosed |