Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP4 | Q02790 | 1/20 | 0.56 |
| ▸ | TACR1 | P25103 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | XIAP | P98170 | 3/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667052 | 0.96 | FKBP4 (0.58) | FKBP4TACR1OPRM1OPRD1OPRK1 | |
| SCHEMBL3277774 | 0.94 | FKBP4 (0.57) | FKBP4TACR1OPRM1OPRD1OPRK1 | |
| SCHEMBL27843840 | 0.94 | F2 (0.54) | FKBP4TACR1OPRM1OPRD1OPRK1 | |
| SCHEMBL1295326 | 0.94 | F2 (0.54) | FKBP4TACR1OPRM1OPRD1OPRK1 | |
| SCHEMBL6058133 | 0.91 | OPRM1 (0.56) | FKBP4TACR1OPRM1OPRD1OPRK1 | |
| SCHEMBL7746384 | 0.91 | KMT2A (0.58) | FKBP4TACR1OPRM1OPRD1OPRK1 | |
| SCHEMBL5833504 | 0.89 | TACR1 (0.53) | FKBP4TACR1XIAPF2PRSS1 | |
| SCHEMBL14027241 | 0.88 | FKBP4 (0.65) | FKBP4TACR1OPRM1OPRD1OPRK1 | |
| SCHEMBL11103910 | 0.87 | FKBP4 (0.58) | FKBP4TACR1OPRM1OPRD1OPRK1 | |
| SCHEMBL7048929 | 0.85 | TACR1 (0.51) | FKBP4TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360173-A2 | TRISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIR USE | GUILFORD PHARMACEUTICALS INC. (US) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002059080-A2 | TRISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIR USE | GUILFORD PHARMACEUTICALS INC. (US) | 2002-08-01 | — | — | WO | disclosed |