Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 13/20 | 1.00 |
| ▸ | NOS3 | P29474 | 7/20 | 1.00 |
| ▸ | NOS1 | P29475 | 9/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6464978 | 0.83 | NOS2 (0.70) | NOS2NOS3NOS1 | |
| SCHEMBL7051196 | 0.83 | NOS2 (1.00) | NOS2NOS3NOS1 | |
| SCHEMBL15259149 | 0.82 | NOS2 (0.69) | NOS2NOS3NOS1 | |
| SCHEMBL5673354 | 0.80 | NOS2 (0.67) | NOS2NOS3NOS1 | |
| SCHEMBL26538156 | 0.79 | NOS2 (1.00) | NOS2NOS3NOS1 | |
| SCHEMBL10399435 | 0.79 | NOS2 (0.65) | NOS2NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL5674986 | 0.78 | NOS2 (0.64) | NOS2NOS3NOS1 | |
| SCHEMBL6279267 | 0.78 | NOS2 (0.71) | NOS2NOS3NOS1 | |
| SCHEMBL17721458 | 0.78 | NOS2 (0.79) | NOS2NOS3NOS1 | |
| SCHEMBL2623106 | 0.77 | NOS2 (0.63) | NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003013523-A1 | SH3 PROTEIN DOMAINS AND THEIR LIGANDS | ADELAIDE RESEARCH & INNOVATION PTY LTD (AU) | 2003-02-20 | — | — | WO | claimed |
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | claimed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | claimed |
| WO-2023131271-A1 | PYRROLE FUSED-RING PYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2023-07-13 | — | — | WO | disclosed |
| WO-2022166920-A1 | PYRROLOPYRIDAZINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2022-08-11 | — | — | WO | disclosed |
| EP-3782991-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | The Scripps Research Institute (US) | 2021-02-24 | — | — | EP | disclosed |
| US-9682950-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160152590-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-06-02 | — | — | US | disclosed |
| US-9242957-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2016-01-26 | — | — | US | disclosed |
| US-20140256958-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-09-11 | — | — | US | disclosed |
| US-8735606-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-03-06 | — | — | US | disclosed |
| WO-2003013523-A1 | SH3 PROTEIN DOMAINS AND THEIR LIGANDS | ADELAIDE RESEARCH & INNOVATION PTY LTD (AU) | 2003-02-20 | — | — | WO | disclosed |
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152590-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors | NOS2, NOS1, NOS3 | NOS2 1/4885NOS3 3/4885NOS1 2/4885 |
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NOS2, NOS1, NOS3 | NOS2 1/4885NOS3 3/4885NOS1 2/4885 |
| US-20140256958-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NOS2, NOS1, NOS3 | NOS2 1/4885NOS3 3/4885NOS1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.