Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 7/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050825 | 0.86 | CCR2 (0.39) | CCR2SRCLMNAMAPTRAB9A | |
| SCHEMBL7947149 | 0.86 | BRD4 (0.46) | BRD4CCR2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7047694 | 0.85 | BRD4 (0.50) | BRD4CCR2LMNAMAPTRAB9A | |
| SCHEMBL7052377 | 0.84 | CCR2 (0.53) | BRD4CCR2LMNAMAPTRAB9A | |
| SCHEMBL7047624 | 0.82 | CCR2 (0.39) | CCR2LMNAMAPTGAAHTT | |
| SCHEMBL7046244 | 0.82 | CCR2 (0.40) | CCR2LMNAMAPTRAB9AGAA | |
| SCHEMBL7048043 | 0.77 | BRD4 (0.44) | BRD4CCR2LMNAMAPTRAB9A | |
| SCHEMBL7047693 | 0.77 | CCR2 (0.48) | CCR2 | |
| SCHEMBL21413199 | 0.74 | BRD4 (0.45) | BRD4CSNK2A2CSNK2BCSNK2A1ABCG2 | |
| SCHEMBL22917038 | 0.74 | BRD4 (0.52) | BRD4CSNK2A2CSNK2BCSNK2A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-B1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | ASTRAZENECA UK LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |