Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947056 | 0.85 | CCR2 (0.55) | CCR2ABCB11LMNAMAPTRAB9A | |
| SCHEMBL7049658 | 0.84 | BRD4 (0.50) | CCR2BRD4LMNAMAPTRAB9A | |
| SCHEMBL7052102 | 0.84 | CCR2 (0.56) | CCR2ABCB11 | |
| SCHEMBL7048043 | 0.83 | BRD4 (0.44) | CCR2ABCB11BRD4LMNAMAPT | |
| SCHEMBL7047694 | 0.81 | BRD4 (0.50) | CCR2BRD4LMNAMAPTRAB9A | |
| SCHEMBL7049651 | 0.80 | RAB9A (0.48) | CCR2BRD4LMNAMAPTRAB9A | |
| SCHEMBL7049034 | 0.80 | CCR2 (0.45) | CCR2ABCB11 | |
| SCHEMBL7048041 | 0.80 | CCR2 (0.45) | CCR2ABCB11 | |
| SCHEMBL7047693 | 0.78 | CCR2 (0.48) | CCR2ABCB11 | |
| SCHEMBL7947149 | 0.78 | BRD4 (0.46) | CCR2BRD4LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-B1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | ASTRAZENECA UK LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |
| EP-1054667-A1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040913-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |