Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 12/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049658 | 0.82 | BRD4 (0.50) | CCR2LMNAGAAMAPTHTT | |
| SCHEMBL7047624 | 0.78 | CCR2 (0.39) | CCR2LMNAGAAMAPTHTT | |
| SCHEMBL7050825 | 0.76 | CCR2 (0.39) | CCR2LMNAGAAMAPTHTT | |
| SCHEMBL8095077 | 0.72 | MAPT (0.40) | LMNAMAPTSMN1; SMN2NPSR1MEN1 | |
| SCHEMBL7947149 | 0.69 | BRD4 (0.46) | CCR2LMNAGAAMAPTHTT | |
| SCHEMBL7047694 | 0.69 | BRD4 (0.50) | CCR2LMNAMAPTSIGMAR1NPC1 | |
| SCHEMBL7047693 | 0.67 | CCR2 (0.48) | CCR2ABCB11 | |
| SCHEMBL7052377 | 0.65 | CCR2 (0.53) | CCR2LMNAMAPTRAB9AABCB11 | |
| SCHEMBL7047270 | 0.65 | MAPT (0.48) | CCR2LMNAGAAMAPTHTT | |
| SCHEMBL289069 | 0.65 | CAPN1 (0.51) | LMNAMAPTHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-B1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | ASTRAZENECA UK LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |