SCHEMBL7050672

SCHEMBL7050672

CC1=Cc2c(-c3cccc4ccccc34)cccc2C1[Si](C)(Cl)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP3 O14638 1/20 0.33
ENPP1 P22413 1/20 0.33
KDM4E B2RXH2 7/20 0.33
ALDH1A1 P00352 6/20 0.33
HPGD P15428 5/20 0.33
MAPT P10636 3/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
HSD17B10 Q99714 3/20 0.33
MAPK1 P28482 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
TSHR P16473 2/20 0.33
TP53 P04637 1/20 0.33
NFKB1 P19838 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
ATM Q13315 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
ALOX15 P16050 5/20 0.32
RAB9A P51151 3/20 0.32
NPC1 O15118 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7054159 0.89 KDM4E (0.33) ENPP3ENPP1KDM4EALDH1A1HPGD
SCHEMBL5836057 0.87 ENPP3 (0.35) ENPP3ENPP1KDM4EALDH1A1HPGD
SCHEMBL7053238 0.87 ENPP3 (0.36) ENPP3ENPP1KDM4EALDH1A1HPGD
SCHEMBL4466994 0.87 ENPP3 (0.36) ENPP3ENPP1KDM4EALDH1A1HPGD
SCHEMBL5837687 0.86 KDM4E (0.35) ENPP3ENPP1KDM4EALDH1A1HPGD
SCHEMBL7054636 0.84 PDCD1 (0.30)
SCHEMBL3149399 0.84 ENPP3 (0.38) ENPP3ENPP1KDM4EALDH1A1HPGD
SCHEMBL7054875 0.84 ENPP3 (0.38) ENPP3ENPP1KDM4EALDH1A1HPGD
Hydrochloric Acid SCHEMBL5167145 0.82 ENPP3 (0.36) ENPP3ENPP1KDM4EALDH1A1HPGD
SCHEMBL1452672 0.78 ENPP3 (0.33) ENPP3ENPP1KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985674-B1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR ALPHA-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING ALPHA-OLEFIN POLYMERS MITSUBISHI CHEM CORP (JP) 2003-04-23 EP disclosed
US-6255515-B1 COORDINATION POLYMERIZATION CATALYSTS MITSUBISHI CHEMICAL CORPORATION (JP) 2001-07-03 US disclosed
EP-0985674-A1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR $g(a)-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING $g(a)-OLEFIN POLYMERS MITSUBISHI CHEMICAL CORPORATION (JP) 2000-03-15 EP disclosed