Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057068 | 0.90 | NPC1 (0.51) | CHEK1MAP4K4IKBKBNPC1MAPT | |
| SCHEMBL7058742 | 0.89 | IKBKB (0.64) | CHEK1IKBKB | |
| SCHEMBL7055932 | 0.84 | CHEK1 (0.59) | CHEK1MAP4K4IKBKBNPC1MAPT | |
| SCHEMBL7055995 | 0.84 | CHEK1 (0.62) | CHEK1MAP4K4IKBKBALOX15NPC1 | |
| SCHEMBL7052328 | 0.84 | CHEK1 (0.78) | CHEK1MAP4K4IKBKBALOX15NPC1 | |
| SCHEMBL7055235 | 0.82 | CHEK1 (0.62) | CHEK1MAP4K4IKBKBNPC1MAPT | |
| SCHEMBL7050462 | 0.78 | CHEK1 (0.54) | CHEK1MAP4K4IKBKBALOX15NPC1 | |
| SCHEMBL7055165 | 0.78 | CHEK1 (0.54) | CHEK1MAP4K4IKBKBMAPTKDM4E | |
| SCHEMBL7058130 | 0.77 | CHEK1 (0.59) | CHEK1MAP4K4IKBKBALOX15NPC1 | |
| SCHEMBL7052959 | 0.76 | CHEK1 (0.49) | CHEK1MAP4K4IKBKBMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |