Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052959 | 0.91 | CHEK1 (0.49) | CHEK1MAP4K4KDM4EALDH1A1HPGD | |
| SCHEMBL7059399 | 0.90 | PTPN1 (0.53) | CHEK1MAP4K4KDM4EALDH1A1HPGD | |
| SCHEMBL7058336 | 0.86 | CHEK1 (0.66) | CHEK1MAP4K4KDM4EALDH1A1HPGD | |
| SCHEMBL7058543 | 0.86 | CHEK1 (0.50) | CHEK1MAP4K4KDM4EALDH1A1HPGD | |
| SCHEMBL7055235 | 0.85 | CHEK1 (0.62) | CHEK1MAP4K4KDM4EALDH1A1HPGD | |
| SCHEMBL7053757 | 0.81 | PTPN1 (0.62) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL7055932 | 0.80 | CHEK1 (0.59) | CHEK1MAP4K4KDM4EALDH1A1HPGD | |
| SCHEMBL7055995 | 0.80 | CHEK1 (0.62) | CHEK1MAP4K4ALDH1A1MAPTGAA | |
| SCHEMBL7052328 | 0.79 | CHEK1 (0.78) | CHEK1MAP4K4KDM4EMAPTIKBKB | |
| SCHEMBL7051467 | 0.78 | CHEK1 (0.56) | CHEK1MAP4K4KDM4EMAPTIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |