Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | IL2 | P60568 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057671 | 0.94 | CHEK1 (0.56) | CHEK1MAP4K4JAK2IL2HDAC6 | |
| SCHEMBL7052328 | 0.86 | CHEK1 (0.78) | CHEK1MAP4K4JAK2NPC1RAB9A | |
| SCHEMBL7055932 | 0.81 | CHEK1 (0.59) | CHEK1MAP4K4JAK2HDAC6NPC1 | |
| SCHEMBL7055995 | 0.79 | CHEK1 (0.62) | CHEK1MAP4K4JAK2HDAC6NPC1 | |
| SCHEMBL7055999 | 0.78 | CHEK1 (0.72) | CHEK1MAP4K4JAK2NPC1RAB9A | |
| SCHEMBL5898639 | 0.77 | JAK2 (0.65) | CHEK1JAK2HDAC6IKBKB | |
| SCHEMBL7051467 | 0.77 | CHEK1 (0.56) | CHEK1MAP4K4NPC1RAB9ANPSR1 | |
| SCHEMBL7055235 | 0.77 | CHEK1 (0.62) | CHEK1MAP4K4HDAC6NPC1KDM4E | |
| SCHEMBL7053485 | 0.77 | JAK2 (0.73) | CHEK1MAP4K4JAK2HDAC6IKBKB | |
| SCHEMBL7059534 | 0.76 | CHEK1 (0.73) | CHEK1MAP4K4JAK2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |