Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 3/20 | 0.40 |
| ▸ | CCR2 | P41597 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045477 | 0.94 | CCR2 (0.44) | ABCB11CCR2MAPTRAB9ALMNA | |
| SCHEMBL7047535 | 0.92 | MRGPRX4 (0.41) | ABCB11CCR2MAPTRAB9AFABP4 | |
| SCHEMBL7050840 | 0.88 | CCR2 (0.41) | ABCB11CCR2MAPTRAB9ALMNA | |
| SCHEMBL7048128 | 0.88 | CCR2 (0.45) | ABCB11CCR2MAPTRAB9ALMNA | |
| SCHEMBL7158730 | 0.86 | RAB9A (0.46) | ABCB11MAPTRAB9ALMNAHDAC1 | |
| SCHEMBL7954542 | 0.85 | CCR2 (0.39) | ABCB11CCR2MAPTRAB9ALMNA | |
| SCHEMBL7050228 | 0.85 | CCR2 (0.39) | ABCB11CCR2MAPTRAB9ALMNA | |
| SCHEMBL7050361 | 0.82 | TSHR (0.43) | ABCB11CCR2MAPTRAB9ALMNA | |
| SCHEMBL7048313 | 0.79 | HDAC1 (0.52) | ABCB11CCR2MAPTRAB9ALMNA | |
| SCHEMBL7047693 | 0.75 | CCR2 (0.48) | ABCB11CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-B1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | ASTRAZENECA UK LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |