Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050228 | 0.98 | CCR2 (0.39) | CCR2ABCB11LMNAMAPTRAB9A | |
| SCHEMBL7050840 | 0.89 | CCR2 (0.41) | CCR2ABCB11LMNAMAPTRAB9A | |
| SCHEMBL7048128 | 0.87 | CCR2 (0.45) | CCR2ABCB11LMNAMAPTRAB9A | |
| SCHEMBL7045477 | 0.86 | CCR2 (0.44) | CCR2ABCB11LMNAMAPTRAB9A | |
| SCHEMBL7051845 | 0.85 | ABCB11 (0.40) | CCR2ABCB11LMNAMAPTRAB9A | |
| SCHEMBL7047535 | 0.82 | MRGPRX4 (0.41) | CCR2ABCB11MAPTRAB9AHTT | |
| SCHEMBL7050361 | 0.81 | TSHR (0.43) | CCR2ABCB11LMNAMAPTRAB9A | |
| SCHEMBL7048313 | 0.78 | HDAC1 (0.52) | CCR2ABCB11LMNAMAPTRAB9A | |
| SCHEMBL7954546 | 0.77 | HDAC1 (0.46) | CCR2ABCB11LMNAMAPTRAB9A | |
| SCHEMBL7050230 | 0.76 | HDAC1 (0.45) | CCR2ABCB11LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |