Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 8/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045477 | 0.92 | CCR2 (0.44) | CCR2RAB9AFABP4ABCB11MAPT | |
| SCHEMBL7051845 | 0.92 | ABCB11 (0.40) | CCR2RAB9AFABP4ABCB11MAPT | |
| SCHEMBL7048477 | 0.87 | TP53 (0.40) | MRGPRX4RAB9ATP53MAPTHTT | |
| SCHEMBL7050840 | 0.85 | CCR2 (0.41) | CCR2RAB9AABCB11MAPTHTT | |
| SCHEMBL7048128 | 0.85 | CCR2 (0.45) | CCR2RAB9AABCB11MAPTHTT | |
| SCHEMBL7050228 | 0.84 | CCR2 (0.39) | CCR2RAB9AABCB11MAPTHTT | |
| SCHEMBL7954542 | 0.82 | CCR2 (0.39) | CCR2RAB9AABCB11MAPTHTT | |
| SCHEMBL7158730 | 0.80 | RAB9A (0.46) | RAB9AABCB11TP53MAPTHTT | |
| SCHEMBL7050361 | 0.79 | TSHR (0.43) | CCR2RAB9AABCB11TP53MAPT | |
| SCHEMBL7048313 | 0.76 | HDAC1 (0.52) | CCR2RAB9AABCB11MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-B1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | ASTRAZENECA UK LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |