Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PPM1B | O75688 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320339 | 0.92 | ALDH1A1 (0.41) | GAANOS3NOS2ALDH1A1ALOX15 | |
| SCHEMBL19627195 | 0.84 | ATM (0.35) | GAANOS3NOS2ALDH1A1MAPT | |
| SCHEMBL8484640 | 0.81 | CHRM1 (0.36) | GAANOS3NOS2ALDH1A1L3MBTL1 | |
| SCHEMBL7959569 | 0.78 | TSHR (0.40) | ALDH1A1MAPTTSHRPOLBSMN1; SMN2 | |
| SCHEMBL1100523 | 0.75 | GAA (0.38) | GAAALDH1A1ALOX15MAPTL3MBTL1 | |
| SCHEMBL3260314 | 0.74 | GAA (0.36) | GAANOS3NOS2ALDH1A1MAPT | |
| SCHEMBL3843370 | 0.72 | KMT2A (0.50) | GAAALDH1A1ALOX15L3MBTL1THRB | |
| SCHEMBL3838195 | 0.72 | KMT2A (0.46) | GAAALDH1A1ALOX15L3MBTL1THRB | |
| SCHEMBL29822414 | 0.72 | CHRM1 (0.49) | GAAALDH1A1ALOX15L3MBTL1THRB | |
| SCHEMBL1712921 | 0.72 | CHRM1 (0.43) | GAACHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030236405-A1 | A nicotinic acetylcholine receptors, treating neurological and psychological disorders inflamnmatory bowel disease, irritable bowel syndrome, spastic dystonia, pain, vasoconstriction, anxiety, autism, depression, bipolar disorder | YOHANNES DANIEL (US) | 2003-12-25 | — | — | US | disclosed |
| US-20020038028-A1 | For therapy of neurological and psychological disorders are claimed. | YOHANNES DANIEL (US) | 2002-03-28 | — | — | US | disclosed |
| US-20020035262-A1 | 7-hetero-bicyclo[2.2.1]-heptanes | YOHANNES DANIEL (US) | 2002-03-21 | — | — | US | disclosed |
| EP-0955301-A2 | 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylchloline receptors | Pfizer Products Inc. (US) | 1999-11-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020038028-A1 | For therapy of neurological and psychological disorders are claimed. | GRIN2C, PNMT, GRIA4 | GAA 503/4885NOS3 2816/4885NOS2 2771/4885 |
| US-20030236405-A1 | A nicotinic acetylcholine receptors, treating neurological and psychological disorders inflamnmatory bowel disease, irritable bowel syndrome, spastic dystonia, pain, vasoconstriction, anxiety, autism, depression, bipolar disorder | CHRNA1, CHRNA6, CHRNA2 | GAA 2620/4885NOS3 780/4885NOS2 606/4885 |
| US-20020035262-A1 | 7-hetero-bicyclo[2.2.1]-heptanes | GRIN2C, CYP8B1, CYP11B2 | GAA 1748/4885NOS3 4073/4885NOS2 3924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.