Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5980166 | 0.91 | ALDH1A1 (0.30) | ALDH1A1RAB9AMAPK1MAPT | |
| Bromide SCHEMBL3845450 | 0.81 | LMNA (0.39) | ALDH1A1RAB9AKDM4ESMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL3850311 | 0.80 | HPGD (0.40) | ALDH1A1RAB9AMAPK1ATMKMT2A | |
| Bromide SCHEMBL5978880 | 0.80 | ALDH1A1 (0.38) | ALDH1A1RAB9AMAPK1MAPTATM | |
| Bromide SCHEMBL3844964 | 0.78 | L3MBTL1 (0.43) | KMT2AMEN1LMNA | |
| Bromide SCHEMBL3848580 | 0.78 | L3MBTL1 (0.43) | KMT2AMEN1LMNA | |
| Bromide SCHEMBL3854345 | 0.78 | L3MBTL1 (0.43) | KMT2AMEN1LMNA | |
| Bromide SCHEMBL7050720 | 0.77 | ALDH1A1 (0.36) | ALDH1A1RAB9AMAPK1MAPTATM | |
| Bromide SCHEMBL5015757 | 0.71 | KMT2A (0.44) | ALDH1A1RAB9AMAPTKMT2AKDM4E | |
| Bromide SCHEMBL7054583 | 0.70 | KMT2A (0.35) | ALDH1A1KMT2AKDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1128830-A4 | REVERSING ADVANCED GLYCOSYLATION CROSS-LINKS USING HETEROCYCLIC-SUBSTITUTED THIAZOLIUM SALTS | ALTEON INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-1128830-A1 | REVERSING ADVANCED GLYCOSYLATION CROSS-LINKS USING HETEROCYCLIC-SUBSTITUTED THIAZOLIUM SALTS | Alteon, Inc. (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027395-A1 | REVERSING ADVANCED GLYCOSYLATION CROSS-LINKS USING HETEROCYCLIC-SUBSTITUTED THIAZOLIUM SALTS | ALTEON, INC. (US) | 2000-05-18 | — | — | WO | disclosed |