Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 8/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.57 |
| ▸ | TUBB | P07437 | 1/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.57 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.57 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057054 | 0.83 | MAPT (0.69) | IKBKBMAPTALDH1A1HDAC6TUBB4A | |
| SCHEMBL4082097 | 0.82 | IKBKB (1.00) | IKBKBMAPTALDH1A1HDAC6TUBB4A | |
| SCHEMBL7055888 | 0.82 | IKBKB (0.77) | IKBKBMAPTALDH1A1HDAC6TUBB4A | |
| SCHEMBL7057234 | 0.81 | IKBKB (0.76) | IKBKBMAPTALDH1A1HDAC6TUBB4A | |
| SCHEMBL7055446 | 0.77 | IKBKB (0.72) | IKBKBMAPTALDH1A1HDAC6TUBB4A | |
| SCHEMBL7055593 | 0.74 | MAPT (0.52) | IKBKBMAPTALDH1A1TUBB4ATUBB | |
| SCHEMBL7057778 | 0.74 | TUBB4A (0.65) | IKBKBMAPTALDH1A1HDAC6TUBB4A | |
| SCHEMBL7056317 | 0.73 | IKBKB (0.76) | IKBKBMAPTALDH1A1HDAC6TUBB4A | |
| SCHEMBL7057171 | 0.71 | PTPN1 (0.72) | IKBKBMAPTALDH1A1HDAC6PTPRF | |
| SCHEMBL7050462 | 0.71 | CHEK1 (0.54) | IKBKBMAPTALDH1A1HDAC6CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |