Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | CASP3 | P42574 | 2/20 | 0.64 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.64 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.60 |
| ▸ | TUBB | P07437 | 3/20 | 0.60 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.60 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.60 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195941 | 0.85 | KDM4E (0.76) | IKBKBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL7057778 | 0.85 | TUBB4A (0.65) | IKBKBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL4097204 | 0.84 | IKBKB (1.00) | IKBKBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL5193028 | 0.84 | IKBKB (0.78) | IKBKBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL7056469 | 0.81 | IKBKB (0.79) | IKBKBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL7057485 | 0.80 | IKBKB (0.63) | IKBKBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL7055593 | 0.80 | MAPT (0.52) | IKBKBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL10725054 | 0.78 | MAPT (1.00) | IKBKBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL7052936 | 0.77 | IKBKB (0.69) | IKBKBMAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL13957585 | 0.77 | GSK3B (0.47) | IKBKBMAPTKDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |