SCHEMBL7052951

SCHEMBL7052951

CCCCCc1ccccc1C=Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHAT P28329 2/20 0.46
LIPG Q9Y5X9 1/20 0.46
TRPA1 O75762 2/20 0.43
NFE2L2 Q16236 2/20 0.43
EGFR P00533 1/20 0.41
CNR1 P21554 1/20 0.41
CYSLTR2 Q9NS75 1/20 0.40
CYSLTR1 Q9Y271 1/20 0.40
TP53 P04637 1/20 0.40
MAPT P10636 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
BID P55957 3/20 0.40
MCL1 Q07820 3/20 0.40
BCL2L1 Q07817 2/20 0.40
BAK1 Q16611 2/20 0.40
KAT8 Q9H7Z6 2/20 0.40
PTGER4 P35408 1/20 0.40
PTGER3 P43115 1/20 0.40
PTGER2 P43116 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11352153 0.98 LIPG (0.49) CHATLIPGTRPA1NFE2L2EGFR
SCHEMBL28845923 0.98 LIPG (0.49) CHATLIPGTRPA1NFE2L2EGFR
SCHEMBL560985 0.95 CHAT (0.47) CHATLIPGTRPA1NFE2L2EGFR
SCHEMBL4326063 0.95 CHAT (0.47) CHATLIPGTRPA1NFE2L2EGFR
SCHEMBL6546316 0.87 CHAT (0.50) CHATTRPA1NFE2L2PTGER4PTGER3
SCHEMBL6546302 0.87 CHAT (0.50) CHATTRPA1NFE2L2PTGER4PTGER3
SCHEMBL5460484 0.86 ALOX5 (0.50) CHATLIPGTRPA1MAPTBID
SCHEMBL5460489 0.85 NFE2L2 (0.47) CHATLIPGTRPA1NFE2L2BID
SCHEMBL2496686 0.82 CYSLTR2 (0.41) CHATLIPGTRPA1NFE2L2EGFR
SCHEMBL9393856 0.82 CHAT (0.43) CHATLIPGTRPA1NFE2L2EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6706839-B1 COVALENTLY BONDING SEPARATING AGENT TO REACTANT; ISOMERIZATION UNIVERSITY OF PITTSBURGH 2004-03-16 US disclosed
EP-1165222-A4 CHEMICAL PARTITIONING AGENTS AND METHODS OF USING SAME UNIV PITTSBURGH (US) 2003-05-21 EP disclosed
EP-1165222-A1 CHEMICAL PARTITIONING AGENTS AND METHODS OF USING SAME UNIVERSITY OF PITTSBURGH (US) 2002-01-02 EP disclosed
WO-2000047031-A2 CHEMICAL PARTITIONING AGENTS AND METHODS OF USING SAME UNIVERSITY OF PITTSBURGH (US) 2000-08-17 WO disclosed