Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 5/20 | 0.36 |
| ▸ | THRB | P10828 | 5/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARG | Q86W56 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051600 | 0.87 | NR3C1 (0.53) | NR3C1RORCTHRBLPAR1THRA | |
| SCHEMBL7051707 | 0.76 | NR3C1 (0.74) | NR3C1THRBTHRA | |
| SCHEMBL7687151 | 0.75 | NR3C1 (0.62) | NR3C1RORCTHRBLPAR1THRA | |
| SCHEMBL7054408 | 0.75 | NR3C1 (0.50) | NR3C1SMN1; SMN2LMNATHRBNPC1 | |
| SCHEMBL7053492 | 0.74 | NR3C1 (0.58) | NR3C1LMNARORCTHRBNPSR1 | |
| SCHEMBL7054414 | 0.73 | KMT2A (0.50) | NR3C1SMN1; SMN2LMNAGAANPSR1 | |
| SCHEMBL7055432 | 0.73 | NR3C1 (0.73) | NR3C1LPAR1GAANPC1RAB9A | |
| SCHEMBL7052346 | 0.70 | NR3C1 (0.64) | NR3C1THRBTHRA | |
| SCHEMBL7054486 | 0.70 | NR3C1 (0.82) | NR3C1THRBTHRA | |
| SCHEMBL7051598 | 0.69 | NR3C1 (0.53) | NR3C1THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | claimed |