Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050948 | 0.88 | IKBKB (0.80) | IKBKBPTPN1HPGDALDH1A1KDM4E | |
| SCHEMBL7056469 | 0.88 | IKBKB (0.79) | IKBKBPTPN1HPGDALDH1A1KDM4E | |
| SCHEMBL7053757 | 0.86 | PTPN1 (0.62) | IKBKBPTPN1HPGDALDH1A1KDM4E | |
| SCHEMBL7051768 | 0.85 | IKBKB (0.64) | IKBKBPTPN1HPGDMAPT | |
| SCHEMBL7052069 | 0.81 | IKBKB (0.55) | IKBKBPTPN1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL7055235 | 0.81 | CHEK1 (0.62) | IKBKBPTPN1HPGDALDH1A1KDM4E | |
| SCHEMBL7055446 | 0.80 | IKBKB (0.72) | IKBKBPTPN1HPGDALDH1A1KDM4E | |
| SCHEMBL7057270 | 0.77 | MAPT (0.76) | IKBKBHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL23452054 | 0.76 | KDM4E (0.61) | IKBKBPTPN1HPGDALDH1A1KDM4E | |
| SCHEMBL5361893 | 0.76 | KDM4E (0.79) | IKBKBPTPN1HPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |