Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 9/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057485 | 0.85 | IKBKB (0.63) | IKBKBPTPN1HPGDMAPT | |
| SCHEMBL874666 | 0.83 | IKBKB (0.55) | IKBKBPTPN1HPGDMAPT | |
| SCHEMBL7052069 | 0.82 | IKBKB (0.55) | IKBKBPTPN1MAPK14RAF1HPGD | |
| SCHEMBL7053757 | 0.80 | PTPN1 (0.62) | IKBKBPTPN1MAPK14RAF1HPGD | |
| SCHEMBL7055995 | 0.78 | CHEK1 (0.62) | IKBKBMAPT | |
| SCHEMBL7050948 | 0.76 | IKBKB (0.80) | IKBKBPTPN1HPGDMAPT | |
| SCHEMBL7056469 | 0.76 | IKBKB (0.79) | IKBKBPTPN1HPGDMAPT | |
| SCHEMBL7053685 | 0.75 | IKBKB (0.78) | IKBKBPTPN1HPGDMAPT | |
| SCHEMBL7058327 | 0.73 | IKBKB (0.58) | IKBKB | |
| SCHEMBL7057270 | 0.73 | MAPT (0.76) | IKBKBHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |