SCHEMBL7054857

SCHEMBL7054857

CC1=Cc2c(C(C)C)cccc2C1[Si](C)(Cl)c1ccccc1

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.31
ALDH1A1 P00352 1/20 0.31
ALOX15 P16050 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7053998 0.88 LMNA (0.32) LMNAALDH1A1ALOX15TSHR
SCHEMBL7052666 0.86 TSHR (0.32) LMNAALDH1A1ALOX15TSHR
SCHEMBL7052105 0.85 TSHR (0.33) LMNAALDH1A1ALOX15TSHR
SCHEMBL7053482 0.84 LMNA (0.35) LMNATSHR
SCHEMBL7056002 0.84 LMNA (0.35) LMNATSHR
SCHEMBL7037674 0.81 LMNA (0.34) LMNAALDH1A1ALOX15TSHR
SCHEMBL7053648 0.81 LMNA (0.34) LMNAALDH1A1ALOX15TSHR
SCHEMBL7937807 0.80 ALDH1A1 (0.30) ALDH1A1ALOX15TSHR
SCHEMBL7054636 0.80 PDCD1 (0.30)
SCHEMBL1453227 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985674-B1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR ALPHA-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING ALPHA-OLEFIN POLYMERS MITSUBISHI CHEM CORP (JP) 2003-04-23 EP disclosed
US-6255515-B1 COORDINATION POLYMERIZATION CATALYSTS MITSUBISHI CHEMICAL CORPORATION (JP) 2001-07-03 US disclosed
EP-0985674-A1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR $g(a)-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING $g(a)-OLEFIN POLYMERS MITSUBISHI CHEMICAL CORPORATION (JP) 2000-03-15 EP disclosed