Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 7/20 | 0.52 |
| ▸ | DRD2 | P14416 | 6/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | DRD5 | P21918 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057457 | 0.89 | DRD3 (0.54) | DRD3DRD2HTR1ADRD4 | |
| SCHEMBL948083 | 0.85 | DRD2 (0.71) | HTR7DRD3DRD2HTR1AALDH1A1 | |
| SCHEMBL30080790 | 0.85 | DRD2 (0.71) | HTR7DRD3DRD2HTR1AALDH1A1 | |
| SCHEMBL7056834 | 0.84 | HTR1A (0.56) | HTR7DRD3DRD2HTR1AALDH1A1 | |
| SCHEMBL6954563 | 0.81 | HTR1A (0.71) | HTR7DRD3DRD2HTR1AALDH1A1 | |
| SCHEMBL27678005 | 0.78 | DRD2 (0.54) | HTR7DRD3DRD2HTR1AMEN1 | |
| SCHEMBL7057411 | 0.78 | HTR1A (0.49) | HTR7DRD3DRD2HTR1AALDH1A1 | |
| SCHEMBL6246397 | 0.77 | DRD2 (0.69) | HTR7DRD3DRD2HTR1AMEN1 | |
| SCHEMBL7054984 | 0.74 | HTR7 (0.68) | HTR7DRD3DRD2HTR1AALDH1A1 | |
| SCHEMBL7053849 | 0.73 | DRD3 (0.56) | DRD3DRD2HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |