Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.62 |
| ▸ | IKBKB | O14920 | 6/20 | 0.60 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.46 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.46 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057485 | 0.86 | IKBKB (0.63) | PTPN1IKBKBHPGDKDM4EMAPT | |
| SCHEMBL7057778 | 0.81 | TUBB4A (0.65) | PTPN1IKBKBTUBB4ATUBBTUBA3C | |
| SCHEMBL7055165 | 0.81 | CHEK1 (0.54) | PTPN1IKBKBTUBB4ATUBBTUBA3C | |
| SCHEMBL7051768 | 0.80 | IKBKB (0.64) | PTPN1IKBKBHPGDMAPTMAPK14 | |
| SCHEMBL7050948 | 0.78 | IKBKB (0.80) | PTPN1IKBKBHPGDKDM4EMAPT | |
| SCHEMBL7056469 | 0.78 | IKBKB (0.79) | PTPN1IKBKBHPGDKDM4EMAPT | |
| SCHEMBL6313193 | 0.77 | PTPN1 (1.00) | PTPN1IKBKBTUBB4ATUBBTUBA3C | |
| SCHEMBL7052069 | 0.76 | IKBKB (0.55) | PTPN1IKBKBHPGDMEN1KMT2A | |
| SCHEMBL7059399 | 0.76 | PTPN1 (0.53) | PTPN1IKBKBTUBB4ATUBBTUBA3C | |
| SCHEMBL16404527 | 0.75 | IKBKB (0.49) | PTPN1IKBKBTUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |