Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.48 |
| ▸ | PDE4A | P27815 | 12/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.48 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052278 | 0.87 | PDE4D (0.52) | PDE4BPDE4DPDE4APDE4CMKNK2 | |
| SCHEMBL7051176 | 0.85 | PDE4A (0.41) | PDE4BPDE4DPDE4APDE4CCYP1A1 | |
| SCHEMBL7053044 | 0.84 | PDE4A (0.41) | PDE4BPDE4DPDE4APDE4CCCNC | |
| SCHEMBL7055258 | 0.81 | PDE4A (0.45) | PDE4BPDE4DPDE4APDE4CMKNK1 | |
| SCHEMBL7402562 | 0.80 | CYP1A1 (0.39) | PDE4BPDE4DPDE4APDE4CCYP1A1 | |
| SCHEMBL7053150 | 0.80 | AAK1 (0.40) | PDE4BPDE4DPDE4APDE4CMKNK1 | |
| SCHEMBL7056667 | 0.80 | PDE4A (0.42) | PDE4BPDE4DPDE4APDE4CMKNK2 | |
| SCHEMBL7048142 | 0.78 | PDE4A (0.42) | PDE4BPDE4DPDE4APDE4CMKNK2 | |
| SCHEMBL7052696 | 0.78 | PDE4D (0.44) | PDE4BPDE4DPDE4APDE4CMKNK2 | |
| SCHEMBL7054012 | 0.77 | IKBKB (0.39) | PDE4BPDE4DPDE4APDE4CMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |