Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | VEGFA | P15692 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426375 | 0.78 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DNR3C1 | |
| SCHEMBL7054809 | 0.76 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DNR3C1 | |
| SCHEMBL2471687 | 0.74 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DNR3C1 | |
| SCHEMBL14492203 | 0.74 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DGFER | |
| SCHEMBL1494013 | 0.74 | NR3C1 (0.64) | PDE4APDE4BPDE4CPDE4DNR3C1 | |
| SCHEMBL34463204 | 0.73 | MAP1LC3B (0.50) | ALDH1A1LMNAMAPT | |
| SCHEMBL3536936 | 0.72 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DNR3C1 | |
| Ammonia Solution, Strong SCHEMBL7288975 | 0.72 | NR3C1 (0.62) | PDE4APDE4BPDE4CPDE4DNR3C1 | |
| SCHEMBL7293719 | 0.72 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL7052450 | 0.72 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940387-B1 | PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME | MITSUBISHI PHARMA CORP (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-6069176-A | PHENYLETHANOLAMINE COMPOUNDS WITH A BETA-3 ADRENERGIC RECEPTOR STIMULATING EFFECT, USE AS A THERAPY FOR URINARY INCONTINENCE | MITSUBISHI-TOKYO PHARMACEUTICALS, INC. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0940387-A1 | PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME | TOKYO TANABE COMPANY LIMITED (JP) | 1999-09-08 | — | — | EP | disclosed |