Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.45 |
| ▸ | HTR3B | O95264 | 2/20 | 0.45 |
| ▸ | HTR3A | P46098 | 2/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190135 | 0.83 | HTR6 (0.61) | CHRNB2CHRNA4NCF1HTR6HTR3E | |
| SCHEMBL6195559 | 0.82 | HTR3E (0.58) | CHRNB2CHRNA4NCF1HTR6HTR3E | |
| SCHEMBL6194097 | 0.82 | SLC6A2 (0.52) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL10621024 | 0.81 | SLC6A4 (0.51) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL5987323 | 0.81 | SLC6A4 (0.51) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7055686 | 0.79 | HTR1A (0.50) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL255189 | 0.78 | HTR1A (0.68) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7524534 | 0.78 | HTR1A (0.68) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL16528267 | 0.77 | MAPT (0.69) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| Bromide SCHEMBL10621563 | 0.77 | HTR1A (0.66) | HTR6HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |