Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874783 | 0.84 | IKBKB (0.48) | IKBKBMEN1KMT2APTPN1APP | |
| SCHEMBL7051768 | 0.82 | IKBKB (0.64) | IKBKBPTPN1RAF1MAPK14HPGD | |
| SCHEMBL7055593 | 0.81 | MAPT (0.52) | IKBKBMEN1KMT2AAPPRAB9A | |
| SCHEMBL7057485 | 0.81 | IKBKB (0.63) | IKBKBPTPN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7053757 | 0.76 | PTPN1 (0.62) | IKBKBMEN1KMT2APTPN1RAF1 | |
| SCHEMBL874565 | 0.72 | PTPN1 (0.55) | MEN1KMT2APTPN1APPCSNK2A2 | |
| SCHEMBL7053685 | 0.71 | IKBKB (0.78) | IKBKBMEN1KMT2APTPN1LMNA | |
| SCHEMBL7050948 | 0.70 | IKBKB (0.80) | IKBKBPTPN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7056469 | 0.70 | IKBKB (0.79) | IKBKBPTPN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL7057270 | 0.69 | MAPT (0.76) | IKBKBMEN1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |