Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6682813 | 0.71 | P2RX7 (0.36) | HPGDMAPK1EPHX2P2RX7TSHR | |
| SCHEMBL7057795 | 0.69 | HSD11B1 (0.51) | LMNAHPGDMAPK1EPHX2P2RX7 | |
| SCHEMBL14570637 | 0.68 | DPP4 (0.36) | HSD11B1 | |
| SCHEMBL14267061 | 0.67 | HPGD (0.42) | HPGDMAPK1EPHX2P2RX7HTT | |
| SCHEMBL14267070 | 0.66 | HPGD (0.41) | HPGDMAPK1EPHX2P2RX7HSD17B10 | |
| SCHEMBL6684554 | 0.64 | GRIN2D (0.37) | HPGDMAPK1EPHX2P2RX7TSHR | |
| SCHEMBL3152561 | 0.63 | DPP4 (0.35) | HPGDEPHX2KDM4EALDH1A1 | |
| SCHEMBL3155476 | 0.63 | DPP4 (0.36) | HPGDHSD11B1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6682911 | 0.63 | OPRK1 (0.38) | HPGDMAPK1EPHX2P2RX7HTT | |
| SCHEMBL2845610 | 0.62 | CYP19A1 (0.49) | EPHX2P2RX7HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1305306-A2 | 2-ADAMANTYLETHYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002008219-A2 | 2-ADAMANTYLETHYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2002-01-31 | — | — | WO | disclosed |