Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.36 |
| ▸ | CTSC | P53634 | 3/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3152561 | 0.98 | DPP4 (0.35) | DPP4CTSCDPP7CYP3A4DPP8 | |
| SCHEMBL14570637 | 0.76 | DPP4 (0.36) | DPP4CTSCDPP7DPP8DPP9 | |
| SCHEMBL3147114 | 0.69 | HSD11B1 (0.43) | CYP3A4HPGDALDH1A1USP2GRIN2B | |
| SCHEMBL3152655 | 0.69 | HSD11B1 (0.43) | CYP3A4HPGDALDH1A1USP2GRIN2B | |
| SCHEMBL3147106 | 0.69 | HSD11B1 (0.43) | CYP3A4HPGDALDH1A1USP2GRIN2B | |
| SCHEMBL3152647 | 0.69 | HSD11B1 (0.43) | CYP3A4HPGDALDH1A1USP2GRIN2B | |
| SCHEMBL6725338 | 0.69 | HSD11B1 (0.43) | CYP3A4HPGDALDH1A1USP2GRIN2B | |
| SCHEMBL7198425 | 0.68 | DPP4 (0.33) | DPP4DPP7CYP3A4HPGDALDH1A1 | |
| SCHEMBL7057795 | 0.67 | HSD11B1 (0.51) | CTSCHPGDHSD11B1 | |
| SCHEMBL6736321 | 0.67 | ALDH1A1 (0.49) | CYP3A4HPGDALDH1A1USP2GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379494-B1 | FUSED BICYCLIC OR TRICYCLIC AMINO ACIDS | WARNER LAMBERT CO (US) | 2010-03-10 | — | — | EP | disclosed |
| US-20040092591-A1 | Therapeutic use of fused bicyclic or tricyclic amino acids | BLAKEMORE DAVID CLIVE (GB) | 2004-05-13 | — | — | US | disclosed |
| US-6596900-B2 | Brain, nervous system, neurodegenerative, gastrointestinal, sleep, rheumatic, and psychological disorders; analgesics, antiepileptic agents | PFIZER INC | 2003-07-22 | — | — | US | disclosed |
| US-20030078300-A1 | Fused bicyclic or tricyclic amino acids | PFIZER INC. | 2003-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078300-A1 | Fused bicyclic or tricyclic amino acids | AADAT, SLC1A2, BCAT1 | DPP4 195/4885CTSC 183/4885DPP7 324/4885 |
| US-20040092591-A1 | Therapeutic use of fused bicyclic or tricyclic amino acids | BCAT1, BCAT2, AADAT | DPP4 1916/4885CTSC 829/4885DPP7 1845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.