Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RBP4 | P02753 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14852278 | 0.84 | BACE1 (0.55) | ALDH1A1MAPTRBP4LMNA | |
| SCHEMBL28094402 | 0.83 | ALDH1A1 (0.49) | ALDH1A1POLBMAPTMEN1KMT2A | |
| SCHEMBL15774983 | 0.81 | HTT (0.52) | ALDH1A1POLBMAPTRBP4MEN1 | |
| SCHEMBL2799605 | 0.80 | DRD2 (0.60) | ALDH1A1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL3904994 | 0.79 | KMT2A (0.68) | ALDH1A1POLBMEN1KMT2AAKR1C3 | |
| SCHEMBL20899604 | 0.79 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL19212228 | 0.78 | ALDH1A1 (0.58) | ALDH1A1KDM4EPOLBMAPTRBP4 | |
| SCHEMBL28840342 | 0.78 | POLB (0.42) | ALDH1A1KDM4EPOLBMAPTRBP4 | |
| SCHEMBL8187608 | 0.78 | TACR3 (0.51) | ALDH1A1KDM4EPOLBMAPTMEN1 | |
| SCHEMBL766289 | 0.77 | RBP4 (0.74) | ALDH1A1KDM4EMAPTRBP4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005774-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| EP-3027601-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2017-10-25 | — | — | EP | disclosed |
| US-20160368918-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2016-12-22 | — | — | US | disclosed |
| US-9376441-B2 | Substituted pyrrolidines as SYK inhibitors | GILEAD SCIENCES, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20150038488-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2015-02-05 | — | — | US | disclosed |
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038488-A1 | SYK INHIBITORS | SYK, BTK, LYN | ALDH1A1 4200/4885KDM4E 454/4885POLB 3881/4885 |
| US-20160368918-A1 | SYK INHIBITORS | SYK, BTK, LYN | ALDH1A1 4181/4885KDM4E 527/4885POLB 3783/4885 |
| US-10005774-B2 | Syk inhibitors | SYK, BTK, LYN | ALDH1A1 4181/4885KDM4E 527/4885POLB 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.