Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25475425 | 1.00 | ALDH1A1 (0.32) | ALDH1A1LMNAKMT2AMAPTCYP3A4 | |
| SCHEMBL3302863 | 1.00 | ALDH1A1 (0.32) | ALDH1A1LMNAKMT2AMAPTCYP3A4 | |
| SCHEMBL8867224 | 0.90 | MMP2 (0.39) | ALDH1A1MAPTCYP3A4MMP2ANPEP | |
| SCHEMBL8866598 | 0.90 | MMP2 (0.39) | ALDH1A1MAPTCYP3A4MMP2ANPEP | |
| SCHEMBL3303917 | 0.88 | MEN1 (0.36) | ALDH1A1KMT2AMAPTCYP3A4TSHR | |
| SCHEMBL24166249 | 0.88 | MEN1 (0.36) | ALDH1A1KMT2AMAPTCYP3A4TSHR | |
| SCHEMBL6606249 | 0.87 | ALDH1A1 (0.34) | ALDH1A1LMNAKMT2AMAPTCYP3A4 | |
| SCHEMBL6611656 | 0.84 | ALDH1A1 (0.30) | ALDH1A1LMNAKMT2AMAPTCYP3A4 | |
| SCHEMBL6611658 | 0.84 | ALDH1A1 (0.30) | ALDH1A1LMNAKMT2AMAPTCYP3A4 | |
| SCHEMBL13390232 | 0.84 | TSHR (0.36) | MMP2ANPEPTSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208087-B1 | DIESTER PRODRUGS OF A DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| US-6486175-B1 | Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid | ELI LILLY AND COMPANY | 2002-11-26 | — | — | US | disclosed |
| US-6242462-B1 | NOVEL DECAHYDROISOQUINOLINE DERIVATIVES WHICH ARE SELECTIVE GLUR5 RECEPTOR ANTAGONISTS. | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |