Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7213591 | 0.84 | SMN1; SMN2 (0.39) | HPGDALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL7067440 | 0.84 | MAPK1 (0.41) | ALDH1A1SMN1; SMN2PDGFRBMAPK1 | |
| SCHEMBL1267770 | 0.83 | HPGD (0.39) | IDH1HPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL5500501 | 0.81 | SMN1; SMN2 (0.38) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5673498 | 0.79 | SMN1; SMN2 (0.36) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1917870 | 0.78 | ADORA3 (0.50) | HPGDALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL12068347 | 0.78 | GSK3B (0.49) | ALDH1A1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL25610999 | 0.78 | SMN1; SMN2 (0.38) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8723967 | 0.78 | NOTUM (0.39) | SMN1; SMN2KDM4EMEN1KMT2ARAB9A | |
| SCHEMBL14895111 | 0.78 | LOXL2 (0.47) | HPGDALDH1A1SMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047601-A1 | NOVEL 11-O-SUBSTITUTED KETOLIDE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047600-A1 | 11-O-SUBSTITUTED MACROLIDES AND THEIR DESCLADINOSE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2003-06-12 | — | — | WO | disclosed |