Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | CHRND | Q07001 | 5/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571008 | 0.83 | PTPN1 (0.58) | PTPN1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7127958 | 0.76 | PTPN1 (0.60) | PTPN1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL29283680 | 0.74 | CHRNB2 (0.62) | PTPN1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL6831292 | 0.69 | PTPRB (0.50) | PTPN1 | |
| SCHEMBL7569835 | 0.68 | PTPN1 (0.67) | PTPN1 | |
| SCHEMBL7571014 | 0.68 | PTPN1 (0.52) | PTPN1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7127951 | 0.68 | CHRNB2 (0.47) | PTPN1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL14113280 | 0.66 | ACE (0.62) | FAAH | |
| SCHEMBL10655849 | 0.66 | ACE (0.62) | FAAH | |
| SCHEMBL6918308 | 0.66 | PTPN1 (0.69) | PTPN1CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313696-A2 | AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018323-A2 | AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ABBOTT LABORATORIES (US) | 2002-03-07 | — | — | WO | disclosed |