Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817723 | 0.89 | CRHR1 (0.38) | CRHR1UTS2RMAPK1HTTSMN1; SMN2 | |
| SCHEMBL6819213 | 0.88 | MEN1 (0.39) | PIK3CAPIK3CBPIK3CGHTTSMN1; SMN2 | |
| SCHEMBL6814129 | 0.85 | PRKCQ (0.38) | CRHR1PIK3CAPIK3CBPIK3CGSTK17A | |
| SCHEMBL6817813 | 0.84 | PRKCQ (0.39) | PIK3CAPIK3CBPIK3CGSTK17AHTT | |
| SCHEMBL6817779 | 0.80 | MAPT (0.43) | HTTSMN1; SMN2 | |
| SCHEMBL6082337 | 0.79 | CRHR1 (0.39) | CRHR1PIK3CAPIK3CBPIK3CGUTS2R | |
| SCHEMBL6814623 | 0.78 | PIK3CA (0.39) | CNR1PIK3CAPIK3CBPIK3CGHSD11B1 | |
| SCHEMBL6818033 | 0.77 | MAPT (0.43) | HTTSMN1; SMN2 | |
| SCHEMBL253175 | 0.77 | L3MBTL1 (0.44) | L3MBTL1UTS2RHCAR3MAPK1HTT | |
| SCHEMBL6082104 | 0.77 | PIK3CA (0.42) | PIK3CAPIK3CBPIK3CGHSD11B1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |