Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 10/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 10/20 | 0.34 |
| ▸ | ITGAL | P20701 | 10/20 | 0.34 |
| ▸ | F2R | P25116 | 1/20 | 0.34 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7064160 | 0.90 | F2R (0.38) | GPR183KMT2AKDM4EITGB2ICAM1 | |
| SCHEMBL7065806 | 0.78 | NAMPT (0.36) | IRAK4NAMPTKMT2AKDM4EMEN1 | |
| SCHEMBL7065998 | 0.77 | ITGB2 (0.51) | KDM4EITGB2ICAM1ITGAL | |
| SCHEMBL7063009 | 0.76 | ITGB2 (0.41) | ITGB2ICAM1ITGAL | |
| SCHEMBL7065203 | 0.73 | ITGB2 (0.35) | GPR183ITGB2ICAM1ITGAL | |
| SCHEMBL7612088 | 0.70 | ITGB2 (0.54) | ITGB2ICAM1ITGAL | |
| SCHEMBL7612106 | 0.70 | ITGB2 (0.54) | ITGB2ICAM1ITGAL | |
| SCHEMBL6817246 | 0.69 | F2R (0.42) | GPR183KMT2AMEN1F2R | |
| SCHEMBL6245941 | 0.67 | HPGD (0.39) | KMT2AKDM4EMEN1ITGB2ICAM1 | |
| SCHEMBL6813244 | 0.67 | HRH3 (0.38) | KMT2AMAPK1ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165505-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2004-09-08 | — | — | EP | claimed |